Information

Azithromycin is an antibiotic useful for the treatment of variety of bacterial infections. This includes tympanic cavity infections, streptococcal sore throat, pneumonia, traveler’s diarrhea, and certain other intestinal infections. It's going to even be used for variety of sexually transmitted infections including chlamydia and gonorrhea infections. Alongside other medications, it's going to even be used for malaria.

Azithromycin is an azalide, a kind of macrolide antibiotic. It works by decreasing the assembly of protein, thus stopping bacterial growth.

Dosage

Route of administration: Oral

For bronchitis

Adult dosage (18 years and older): 500 mg once each day for 3 days.

For sinusitis

Adult dosage (18 years and older): 500 mg once each day for 3 days.

Child dosage (6 months to 17 years): 10 mg/kg of weight once each day for 3 days.

Child dosage (0 to six months): This drug shouldn't be utilized in children who are younger than 6 months.

For skin and skin structure infections

Adult dosage (18 years and older): 500 mg during a single dose on day 1, followed by 250 mg once per day on days 2 through 5.

For urethritis and cervicitis

Adult dosage (18 years and older):

. If the infection isn’t caused by gonorrhea, single 1-gram dose is given.

. If the symptoms of gonorrhea infection are seen, one 2-gram dose is given.

For acute tympanic cavity infection

 Child dosage (6 months to 17 years): 10 mg/kg of weight on day 1, followed by 5 mg/kg per day on days 2 through 5.

 Child dosage (0 to six months): This drug shouldn't be utilized in children who are younger than 6 months.

For mycobacterium avium complex disease

Adult dosage (18 years and older): 300-600 mg once per day, crazy the drug ethambutol.

For pharyngitis or tonsillitis

Adult dosage (18 years and older): 500 mg during a single dose on day 1, followed by 250 mg once per day on days 2 through 5.

 Child dosage (2 to 17 years): 12 mg/kg of weight once per day for five days.

Child dosage (0 to 2 years): This drug shouldn't be used for this condition in children who are younger than 2 years

For Cancroid (Genital ulcer)

Adult dosage (18 years or older): 1 gm orally once

Taken with or without food.

Pharmacokinetics

Absorption: Bioavailability is 37% following oral administration

Protein binding: Approximately 51%

Metabolism: Hepatic

Route of elimination: Biliary

Half-life: 68 hours

Mechanism of Action

Azithromycin prevents bacteria from growing by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thus inhibiting translation of mRNA. macromolecule synthesis isn't affected.

Indications

Mild-to-moderate susceptible infections including: acute bacterial exacerbations of COPD*

 acute bacterial sinusitis, acute otitis 

community-acquired pneumonia

 pharyngitis/tonsillitis

 uncomplicated skin and skin structure

urethritis*, cervicitis*, cancroid* in men

Treatment and prophylaxis of Mycobacterium avium complex (MAC) infection.

Adverse Effects

Most common adverse effects are diarrhea, nausea, abdominal pain, and vomiting.

Others: Nervousness, dermatologic reactions, and anaphylaxis

 As with all antimicrobial agents, pseudomembranous colitis can occur during and up to many weeks after azithromycin therapy.

 Contraindications

AZICARE is contraindicated within the following situations:

Hypersensitivity to the active substance or to any of the excipients.

Hepatic Dysfunction

Precautions

Clostridium Difficile-Associated Diarrhea

 QT Prolongation

Drug Interactions

 Nelfinavir: Taking this drug with azithromycin may cause liver or hearing problem.

 Warfarin: Taking this drug with azithromycin may increase bleeding.

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