CAREPRIM-DS
Tablets
Dose Type
Information
This medication, Co-Trimoxazole is a combination of two antibiotics: Sulphamethoxazole 800 mg and trimethoprom 160 mg. It is used to treat a wide variety of bacterial infections (such as middle ear, urine, respiratory, and intestinal infections). It is also used to prevent and treat a certain type of pneumonia.
Therapeutic Class
Careprim-DS is an anti-bacterial sulfonamide, a "sulfa" drug.
Dose and Direction of Use
It may be preferable to take Co-Trimoxazole with some food or drink to minimise the possibility of gastrointestinal disturbances.
Follow the dose and duration of medication as per the prescription.
Mode of Action
Uses
Urinary Tract Infections
Acute Otitis Media
Middle Ear Infections
MRSA skin infections (Methicillin Resistant Staphylococcus aureus)
Respiratory tract infections
Acute Exacerbations of Chronic Bronchitis in Adult
Shigellosis
Pneumocystis Carinii Pneumonia
Traveler's Diarrhea in Adults
Contraindications
Sulfamethoxazole and trimethoprim is contraindicated in:
- patients with a known hypersensitivity to trimethoprim or sulfonamides
- patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides
- patients with documented megaloblastic anemia due to folate deficiency
- pregnant patients and nursing mothers, because sulfonamides pass the placenta and are excreted in the milk and may cause kernicterus
- pediatric patients less than 2 months of age
- patients with marked hepatic damage or with severe renal insufficiency when renal function status cannot be monitored.
Precautions and Warning
Sulfamethoxazole and trimethoprim should be given with caution to patients with impaired renal or hepatic function, to those with possible folate deficiency (e.g., the elderly, chronic alcoholics, patients receiving anticonvulsant therapy, patients with malabsorption syndrome, and patients in malnutrition states) and to those with severe allergies or bronchial asthma.
Patients with renal dysfunction, liver disease, malnutrition or those receiving high doses of sulfamethoxazole and trimethoprim are particularly at risk.
As with all drugs containing sulfonamides, caution is advisable in patients with porphyria or thyroid dysfunction.
