Information

The Active Ingredient of RIFAZEX is Rifaximin, a non-aminoglycoside semi-synthetic, non-systemic antibiotic derived from Rifamycin SV. Rifaximin acts by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase resulting in inhibition of bacterial RNA synthesis.

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Therapeutic Class

Non-Aminoglycoside Semi-Synthetic, Non-Systemic Antibiotic.Anti-diarrheals

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Dose and Direction of Use

To treat Traveller's Diarrhoea , take this medication by mouth with or without food as directed by doctor usually every 8 hours for 3 days.Finish the prescribed amount of the medication or else the infection might return.

To treat irritable bowel syndrome, take this medication by mouth with or without food as directed by doctor 3 times a day for 14 days.

To treat hepatic encephalopathy, take this medication by mouth with or without food as directed by doctor 2 times a day every 12 hours.

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Mode of Action

Rifaximin is an antibacterial drug of the Rifamycin class that irreversibly binds the beta sub-unit of the bacterial enzyme DNA-dependent RNA polymerase and consequently inhibits bacterial RNA synthesis. Rifaximin has a broad antimicrobial spectrum against most of the Gram-positive and negative, aerobic and anaerobic bacteria, including ammonia producing species. Rifaximin may inhibit the division of Urea-Delaminating Bacteria, thereby reducing the production of Ammonia and other compounds that are believed to be important to the pathogenesis of Hepatic Encephalopathy.

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Uses

• Irritable Bowel Syndrome with Diarrhea
• Hepatic Encephalopathy
• Traveler's Diarrhea

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Contraindications

Don't use this medicine if you have:

• Hypersensitivity to Rifaximin, any of the Rifamycin antimicrobial agents, or any of the components in Rifaximin.

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Precautions and Warning

• Talk to your doctor about medical history.
• Discontinue medication if condition worsen or persists >24-48 hours.
• This medication shoule be used only when needed in pregancy as discussed with doctor.
• Do not take two doses at one time.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.

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