Information

Extra Dried Amoxicillin 1000 mg with Clavunate Potassium 200 mg Dry Powder for Injection

Amoxicillin/clavulanic acid, also known as co-amoxiclav, is an antibiotic useful for the treatment of a number of bacterial infections. It is a combination consisting of amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor.

---

Therapeutic Class

Extended Spectrum Antibiotic and Beta Lactamase Inhibitor.

---

Dose and Direction of Use

Co-amoxiclav is for intravenous use.

Co-amoxiclav may be administered either by slow intravenous injection over a period of 3 to 4 min directly into a vein or via a drip tube or by infusion over 30 to 40 min. Co-amoxiclav is not suitable for intramuscular administration.

---

Mode of Action

Amoxicillin is a semisynthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (often referred to as penicillin-binding proteins, PBPs) in the biosynthetic pathway of bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to weakening of the cell wall, which is usually followed by cell lysis and death.Amoxicillin is susceptible to degradation by beta-lactamases produced by resistant bacteria and therefore the spectrum of activity of amoxicillin alone does not include organisms which produce these enzymes.

Clavulanic acid is a beta-lactam structurally related to penicillins. It inactivates some beta-lactamase enzymes thereby preventing inactivation of amoxicillin. Clavulanic acid alone does not exert a clinically useful antibacterial effect

---

Uses

• Severe infections of the ear, nose and throat (such as mastoiditis, peritonsillar infections, epiglottitis, and sinusitis when accompanied by severe systemic signs and symptoms)

• Acute exacerbations of chronic bronchitis (adequately diagnosed)

• Community acquired pneumonia

• Cystitis

• Pyelonephritis

• Skin and soft tissue infections in particular cellulitis, animal bites, severe dental abscess with spreading cellulitis

• Bone and joint infections, in particular osteomyelitis

• Intra-abdominal infections

• Female genital infections.

Prophylaxis against infections associated with major surgical procedures in adults, such as those involving the:

• Gastrointestinal tract

• Pelvic cavity

• Head and neck

• Biliary tract surgery.

---

Contraindications

Don't use this medicine if you have:

• Hypersensitivity to the active substances, to any of the penicillins 
• History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam).
• History of jaundice/hepatic impairment due to amoxicillin/clavulanic acid

---

Precautions and Warning

• Children aged less than 3 months should be administered amoxicillin/clavulanic acid by infusion only.
• Treatment with amoxicillin/clavulanic acid may be initiated by the use of an intravenous preparation and completed with an appropriate oral presentation as considered appropriate for the individual patient.
•  Maintain adequate hydration with high doses (particularly during parenteral therapy).
• Consult with your doctor if you are pregnant or breast feeding woman before taking this medicine to understand the risk and benefit ratio.
• Talk to your doctor about past medical history like kidney problem or liver problem before taking this medicine
• Don't double the dose for the missed one.
• Complete the prescribed dose and duration of medicine.

---