USOLIV 300 is brand name of Ursodiol 300mg. Ursodeoxycholic acid (UDCA), also known as ursodiol is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria . It is indicated in the treatment of primary biliary cirrhosis (PBC) and for the dissolution of small to medium sized radiolucent, cholesterol-rich gall-stones in patients with a functioning gall bladder
Bile Acid Preparations
Dose and Direction of Use
Take the medication as directed by your doctor and as mentioned on the label. Unless told differently, swallow the tablet with water.
Mode of Action
The mechanism of action of UDCA in liver and cholestasis disorders has not yet been explained totally. However, UDCA alters bile acid composition, resulting in increases in the concentration of UDCA and decreases in the concentrations of the more hydrophobic and potentially toxic bile acids, cholic and chenodeoxycholic acids. UDCA also has a choleretic effect, resulting in increased bile acid output and bile flow. There is some evidence for immunological effects, including a reduction of abnormal expression of HLA Class I antigens on hepatocytes and a suppression of immunoglobulin and cytokine production. The Ursodeoxycholic acid converts lithogenic bile in non-lithogenic bile and gradually dissolves the cholesterol gallstones.
1. The dissolution of cholesterol stones in patients:
- With one or more X-ray radiolucent (X-ray negative) gallstones, preferably with a diameter of not more than 2 cm, in a well-functioning gall bladder;
- refusing a surgical procedure or in which surgical intervention is not indicated;
- With whom an oversaturation of cholesterol has been shown by chemical analysis of the bile produced by duodenum drainage.
2. Primary Biliary Cholangitis.
- Pediatric population
3. Hepatobiliary disorder associated with cystic fibrosis in children aged 6 years to 18 years.
Don't use this medicine if you have:
- Hypersensitivity to this medicine
Precautions and Warning
- Have regular liver function test.
- It contains lactose, so consult your doctor if you have tolerance to some sugar.
- Mention if you are taking any other medications like oral contraceptive drugs as it can affect the work of Ursodeoxycholic Acid.
- Not recoomended if you have gall bladder problem, liver problem or peptic ulcers.