ZANTOR 40
Tablet
Dose Type
Information
ZANTOR 40 helps to lower levels of uric acid in the blood. It works by blocking an enzyme in the body called xanthine oxidase and prevent gout flare-ups.
Therapeutic Class
Antihyperuricaemic Agent (Xanthine Oxidase Inhibitor)
Dose and Direction of Use
Swallow the tablet whole by mouth. You can take it with or without food. Don't crush, chew or break the tablet. Follow the dose and duration as prescribed by the doctor.
Mode of Action
Uric acid is the end product of purine metabolism in humans and is generated in the cascade of hypoxanthine → xanthine → uric acid. Both steps in the above transformations are catalyzed by xanthine oxidase (XO).Febuxostat is a 2-arylthiazole derivative that achieves its therapeutic effect of decreasing serum uric acid by selectively inhibiting XO. Febuxostat has been shown to potently inhibit both the oxidized and reduced forms of XO. Thus, uric acid level is reduced.
Uses
Treatment of chronic high level of uric acid in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/ or gouty arthritis).
Contraindications
Don't use this medicine if you have:
- Hypersensitivity to Febuxostat
Precautions and Warning
- Consult with your doctor if you are pregnant or breast feeding woman before taking this medicine to understand the risk and benefit ratio.
- Talk to your doctor about past medical history like kidney problem, heart problem or liver problem before taking this medicine
- Liver function test is recommended prior to the initiation of therapy with febuxostat and periodically thereafter.
- Don't double the dose for the missed one.
- Complete the prescribed dose and duration of medicine.
- It may cause dizziness or drowsiness so avoid any activity that requires concentration unless you know how the medicine acts on you.
- Do not consume alcohol while taking this medicine as it may worsen your gout.
- Take plenty of fluids (2-3 litres) daily while on this medicine.
- Patients should be advised of the signs and symptoms and monitored closely for symptoms of allergic/hypersensitivity reactions. Febuxostat treatment should be immediately stopped if serious allergic/hypersensitivity reactions, including Stevens-Johnson syndrome, occur since early withdrawal is associated with a better prognosis.
